Activation of PPAR enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats
نویسندگان
چکیده
Leonard S. Golfman,* Christopher R. Wilson,* Saumya Sharma, Mathias Burgmaier, Martin E. Young, Patrick H. Guthrie, Melissa Van Arsdall, Julia V. Adrogue, Kathleen K. Brown, and Heinrich Taegtmeyer Division of Cardiology; University of Texas Medical School at Houston; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas; and GlaxoSmithKline, Research Triangle Park, North Carolina
منابع مشابه
Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats.
It is suggested that insulin resistance and metabolic maladaptation of the heart are causes of contractile dysfunction. We tested the hypothesis whether systemic PPARgamma activation, by changing the metabolic profile in a model of insulin resistance and type 2 diabetes (the ZDF rat) in vivo, improves contractile function of the heart in vitro. Male Zucker diabetic fatty (ZDF) and Zucker lean (...
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Hearts from type 2 diabetic (T2DM) subjects are chronically subjected to hyperglycemia and hyperlipidemia, both thought to contribute to oxidizing conditions and contractile dysfunction. How redox alterations and contractility interrelate, ultimately diminishing T2DM heart function, remains poorly understood. Herein we tested whether the fatty acid palmitate (Palm), in addition to its energetic...
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BACKGROUND In vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM). The purpose of the present study was to study in a rat model of early DCM, in vivo changes in myocardial substrate metabolism and their association with myocardial function. METHODS Zucker diabetic fatty (ZDF) and Zucker lean (ZL) ra...
متن کاملImpact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats.
The goal of this study was to determine whether changes in cardiac metabolism in Type 2 diabetes are associated with contractile dysfunction or impaired response to ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats were isolated and perfused with glucose, lactate, pyruvate, and palmitate. The rates of glucose, lactate, pyruvate, and palmitate oxidation rates and glycolysis...
متن کاملThe impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats
The goal of this study was to determine whether changes in cardiac metabolism in Type-2 diabetes were associated with contractile dysfunction or impaired response to ischemia. Hearts from Zucker diabetic fatty rats (ZDF) and lean Controls were isolated, perfused and glucose, lactate, pyruvate and palmitate oxidation rates and glycolytic rates determined during baseline perfusion, low flow ische...
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تاریخ انتشار 2005